4-Fluoromethamphetamine

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4-Fluoromethamphetamine
4-FMA.svg
Ball-and-stick model of the 4-fluoromethamphetamine molecule
Systematic (IUPAC) name
(RS)-1-(4-fluorophenyl)-N-methylpropan-2-amine
Clinical data
Legal status
Identifiers
CAS Number 351-03-1 N
52063-62-4 (hydrochloride)
PubChem CID: 11745017
ChemSpider 9919721 YesY
UNII 8LLF59DO7F YesY
Chemical data
Formula C10H14FN
Molecular mass 167.223 g/mol
  • Fc1ccc(cc1)CC(NC)C
  • InChI=1S/C10H14FN/c1-8(12-2)7-9-3-5-10(11)6-4-9/h3-6,8,12H,7H2,1-2H3 YesY
  • Key:YCWZPIHKUYZTFM-UHFFFAOYSA-N YesY
 NYesY (what is this?)  (verify)

4-Fluoromethamphetamine (4-FMA) is a stimulant drug related to methamphetamine and 4-fluoroamphetamine. It has been reported to be sold on the illicit market as a controlled substance analogue, but little is known about its pharmacology or toxicology as yet.[1] It was first detected from legal highs sold in Japan in 2006 and became illegal to sell or to possess for the purpose of distribution (although not to simply possess for personal use) in Japan in 2008.[2] It was initially reported to be contained as an ingredient in some of the range of party pills sold internationally by the Israeli company Neorganics from around 2006 onwards, but this was later shown to be incorrect and this ingredient was eventually identified as the closely related compound 2-fluoromethamphetamine.[3]

Pharmacology

4-FMA is a CYP450 inhibitor. It reduces the metabolism of methamphetamine, which has the effect of increasing its potency, duration and systemic toxicity while also reducing its cellular toxicity.[4]

Legal Status

China

As of October 2015 4-FMA is a controlled substance in China.[5]

Australia

4-FMA is considered a Schedule 9 substance in Australia under the Poisons Standard (October 2015).[6] A Schedule 9 substance is a substance which may be abused or misused, the manufacture, possession, sale or use of which should be prohibited by law except when required for medical or scientific research, or for analytical, teaching or training purposes with approval of Commonwealth and/or State or Territory Health Authorities.[6]

See also

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References

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  6. ↑ 6.0 6.1 Poisons Standard October 2015 https://www.comlaw.gov.au/Details/F2015L01534
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