UH-232

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UH-232
UH-232 structure.png
Systematic (IUPAC) name
(1S,2R)-5-methoxy-1-methyl-2-(N,N-propylamino)tetralin
Identifiers
CAS Number 95999-12-5 YesY
ATC code none
PubChem CID: 123696
Chemical data
Formula C18H29NO
Molecular mass 275.428 g/mol
  • CC2C(N(CCC)CCC)CCc1c2cccc1OC
  (verify)

UH-232 ((+)-UH232) is a drug which acts as a subtype selective mixed agonist-antagonist for dopamine receptors, acting as a weak partial agonist at the D3 subtype,[1] and an antagonist at D2Sh autoreceptors on dopaminergic nerve terminals.[2][3][4] This causes dopamine release in the brain and has a stimulant effect,[5][6][7] as well as blocking the behavioural effects of cocaine.[8] It was trialled for the treatment of schizophrenia but unexpectedly caused symptoms to become worse.[9]

See also

References

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