Tenidap

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Tenidap
Tenidap.png
Systematic (IUPAC) name
5-chloro-2-hydroxy-3-(2-thienylcarbonyl)-1H-indole-1-carboxamide
Identifiers
ATC code M01AX23 (WHO)
PubChem CID: 60712
ChemSpider 54717
UNII 9K7CJ74ONH N
KEGG D06072 YesY
ChEMBL CHEMBL1097558 N
Chemical data
Formula C14H9ClN2O3S
Molecular mass 320.75086 g/mol
  • c1cc(sc1)C(=O)c2c3cc(ccc3n(c2O)C(=O)N)Cl
  • InChI=1S/C14H9ClN2O3S/c15-7-3-4-9-8(6-7)11(13(19)17(9)14(16)20)12(18)10-2-1-5-21-10/h1-6,19H,(H2,16,20)
  • Key:IZSFDUMVCVVWKW-UHFFFAOYSA-N
 NYesY (what is this?)  (verify)

Tenidap was a COX/5-LOX inhibitor and cytokine-modulating anti-inflammatory drug candidate[1] that was under development by Pfizer as a promising potential treatment for rheumatoid arthritis,[2] but Pfizer halted development after marketing approval was rejected by the FDA in 1996[3] due to liver and kidney toxicity, which was attributed to metabolites of the drug with a thiophene moiety that caused oxidative damage.[4]

References

  1. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ Staff, American Journal of Nursing. Drug Watch: Tenidap Offers Arthritis Therapy Minus Toxicity AJN 1996 96(1):58
  3. ↑ Pfizer. Sept 27, 1996 Press release: Pfizer To Halt Plans For Commercialization Of Tenidap For Rheumatoid Arthritis
  4. ↑ Hwang SH et al. Rationally designed multitarget agents against inflammation and pain. Curr Med Chem. 2013;20(13):1783-99. PMID 23410172 PMC 4113248

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