Fluproquazone

Fluproquazone
Systematic (IUPAC) name
	4-(4-fluorophenyl)-7-methyl-1-propan-2-ylquinazolin-2-one
Identifiers
CAS Number	40507-23-1
ATC code	none
PubChem	CID: 38503
ChemSpider	35289
UNII	U4K85O58HD
KEGG	D04229
Chemical data
Formula	C18H17FN2O
Molecular mass	296.339 g/mol
	SMILES Fc3ccc(C/1=N/C(=O)N(c2cc(ccc\12)C)C(C)C)cc3 ;
	InChI InChI=1S/C18H17FN2O/c1-11(2)21-16-10-12(3)4-9-15(16)17(20-18(21)22)13-5-7-14(19)8-6-13/h4-11H,1-3H3 ; Key:ZWOUXWWGKJBAHQ-UHFFFAOYSA-N ;
(verify)

Fluproquazone (trade name Tormosyl, RF 46-790 ) was a quinazolinone derivative with potent analgesic, antipyretic, and anti-inflammatory effects discovered by Sandoz.^[1]^[2]^[3]^[4] It was withdrawn during development due to liver toxicity.^[5]^:370^[6]^:520

References

↑ Haanaes HR, et al RF 46-790 versus paracetamol: effect on post-operative pain. Int J Clin Pharmacol Ther Toxicol. 1986 Nov;24(11):598-601. PMID 3491794
↑ Mohing W, Suckert R, Lataste X. Comparative study of fluproquazone in the management of post-operative pain. Arzneimittelforschung. 1981;31(5a):918-20.
↑ Wheatley D. Analgesic properties of fluproquazone. Rheumatology and Rehabilitation. 1982 May;21(2):98-100.
↑ Fankhauser S, Laube W, Marti HR, Schultheiss HR, Vogtlin J, von Graffenried B. Antipyretic activity of fluproquazone in man. Arzneimittelforschung. 1981;31(5a):934-5.
↑ Lewis JH and Stine JG. Nonsteroidal Antiinflammatory Drugs and Leukotriene Receptor Antagonists, Ch 22 in Drug-induced Liver Disease (Third Edition). Eds Neil Kaplowitz and Laurie D. DeLeve. Elsevier Inc, 2013. ISBN 9780123878175
↑ Hyman J. Zimmerman. Hepatotoxicity: The Adverse Effects of Drugs and Other Chemicals on the Liver. Lippincott Williams & Wilkins, 1999. ISBN 9780781719520

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[1] Haanaes HR, et al RF 46-790 versus paracetamol: effect on post-operative pain. Int J Clin Pharmacol Ther Toxicol. 1986 Nov;24(11):598-601. PMID 3491794

[2] Mohing W, Suckert R, Lataste X. Comparative study of fluproquazone in the management of post-operative pain. Arzneimittelforschung. 1981;31(5a):918-20.

[3] Wheatley D. Analgesic properties of fluproquazone. Rheumatology and Rehabilitation. 1982 May;21(2):98-100.

[4] Fankhauser S, Laube W, Marti HR, Schultheiss HR, Vogtlin J, von Graffenried B. Antipyretic activity of fluproquazone in man. Arzneimittelforschung. 1981;31(5a):934-5.

[5] Lewis JH and Stine JG. Nonsteroidal Antiinflammatory Drugs and Leukotriene Receptor Antagonists, Ch 22 in Drug-induced Liver Disease (Third Edition). Eds Neil Kaplowitz and Laurie D. DeLeve. Elsevier Inc, 2013. ISBN 9780123878175

[6] Hyman J. Zimmerman. Hepatotoxicity: The Adverse Effects of Drugs and Other Chemicals on the Liver. Lippincott Williams & Wilkins, 1999. ISBN 9780781719520

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v t e Non-steroidal anti-inflammatory drugs (NSAIDs) (primarily M01A and M02A, also N02BA)
Pyrazolones / Pyrazolidines	Aminophenazone Ampyrone Azapropazone Clofezone Famprofazone Feprazone Kebuzone Metamizole Mofebutazone Morazone Nifenazone Oxyphenbutazone Phenazone Phenylbutazone Propyphenazone Sulfinpyrazone Suxibuzone^‡
Salicylates	Aspirin (acetylsalicylic acid)^# Aloxiprin Benorylate Carbasalate calcium Diflunisal Dipyrocetyl Ethenzamide Guacetisal Magnesium salicylate Methyl salicylate Salsalate Salicin Salicylamide Salicylic acid (salicylate) Sodium salicylate
Acetic acid derivatives and related substances	Aceclofenac Acemetacin Alclofenac Amfenac Bendazac Bromfenac Bumadizone Bufexamac Diclofenac Difenpiramide Etodolac Felbinac Fenclozic acid Fentiazac Indomethacin Indomethacin farnesil Isoxepac Ketorolac Lonazolac Oxametacin Prodolic acid Proglumetacin Sulindac Tiopinac Tolmetin Zomepirac^†
Oxicams	Ampiroxicam Droxicam Lornoxicam Meloxicam Piroxicam Tenoxicam
Propionic acid derivatives (profens)	Alminoprofen Benoxaprofen^† Carprofen^‡ Dexibuprofen Dexketoprofen Fenbufen Fenoprofen Flunoxaprofen Flurbiprofen Ibuprofen^# Ibuproxam Indoprofen^† Ketoprofen Loxoprofen Miroprofen Naproxen Oxaprozin Pirprofen Suprofen Tarenflurbil Tepoxalin^‡ Tiaprofenic acid Vedaprofen^‡ COX-inhibiting nitric oxide donator: Naproxcinod
N-Arylanthranilic acids (fenamates)	Azapropazone Etofenamate Flufenamic acid Flunixin Meclofenamic acid Mefenamic acid Morniflumate Niflumic acid Tolfenamic acid Flutiazin
Coxibs	Apricoxib Celecoxib Cimicoxib^‡ Deracoxib^‡ Etoricoxib Firocoxib^‡ Lumiracoxib^† Mavacoxib^‡ Parecoxib Robenacoxib^‡ Rofecoxib^† Valdecoxib^†
Other	Aminopropionitrile Benzydamine Chondroitin sulfate Diacerein Fluproquazone Glucosamine Glycosaminoglycan Hyperforin Nabumetone Nimesulide Oxaceprol Proquazone Superoxide dismutase/Orgotein Tenidap
Items listed in bold indicate initially developed compounds of specific groups. ^#WHO-EM ^†Withdrawn drugs. ^‡Veterinary use medications.

Fluproquazone

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