Quinupramine

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Quinupramine
Quinupramine.png
Systematic (IUPAC) name
(±)-11-quinuclidin-3-yl-5,6-dihydrobenzo[b][1]benzazepine
Clinical data
Legal status
  • ℞ (Prescription only)
Routes of
administration		 Oral
Pharmacokinetic data
Biological half-life 33 hours
Identifiers
CAS Number 31721-17-2
ATC code N06AA23 (WHO)
PubChem CID: 93154
ChemSpider 84098
UNII 29O61HFF4L YesY
KEGG D07336
Chemical data
Formula C21H24N2
Molecular mass 304.43 g/mol

Quinupramine (Kevopril, Kinupril, Adeprim, Quinuprine) is a tricyclic antidepressant (TCA) used in Europe for the treatment of depression.[1][2]

Pharmacologically, quinupramine acts in vitro as a strong muscarinic acetylcholine receptor antagonist (anticholinergic) and H1 receptor antagonist (antihistamine), moderate 5-HT2 receptor antagonist, and weak serotonin and norepinephrine reuptake inhibitor.[3] It has negligible affinity for the α1-adrenergic, α2-adrenergic, β-adrenergic, or D2 receptor.[3]

Clinically, quinupramine is reported to be stimulating similarly to imipramine, desipramine, and demexiptiline.[4] It can be inferred that its in vivo metabolites may have stronger effects on the reuptake of norepinephrine and/or serotonin than quinupramine itself.[citation needed]

References

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