GPR158
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Probable G-protein coupled receptor 158 is a protein that in humans is encoded by the GPR158 gene.[1]
GPR158 is an orphan class C GPCR. It is highly expressed in the brain where it binds to RGS7, an inhibitor of Gi/o-coupled GPCR signaling, localizing it to the plasma membrane.[2]
GPR158 is also expressed at lower levels in other organs. It shows an unusual subcellular localization pattern, being found at both the plasma membrane and in the nucleus.[3]
GPR158 is an androgen-regulated gene that stimulates cell proliferation in prostate cancer cell lines. It is linked to neuroendocrine differentiation.[4]
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