FZD3
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Frizzled-3 is a protein that in humans is encoded by the FZD3 gene.[1][2][3]
Function
This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. It may play a role in mammalian hair follicle development.[3]
The function of this gene is largely derived from mouse studies. Fzd3 in the mouse functions through planar cell polarity signaling instead of the canonical Wnt/beta-catenin pathway. Fzd3 controls axon growth and guidance in the mouse nervous system, and migration of neural crest cells.[4][5]
See also
References
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<references />, or <references group="..." />Further reading
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External links
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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