UGT2A1

UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
Identifiers
Symbols	UGT2A1 ; UDPGT2A1
External IDs	OMIM: 604716 MGI: 2149905 HomoloGene: 136808 ChEMBL: 1743321 GeneCards: UGT2A1 Gene
EC number	2.4.1.17
Gene ontology Molecular function • glucuronosyltransferase activity Cellular component • integral component of membrane • intracellular membrane-bounded organelle Biological process • sensory perception of smell • metabolic process • detection of chemical stimulus • flavonoid biosynthetic process • cellular response to hormone stimulus • cellular glucuronidation • flavonoid glucuronidation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10941	94215
Ensembl	ENSG00000173610	ENSMUSG00000029268
UniProt	Q9Y4X1	Q80X89
RefSeq (mRNA)	NM_001252274	NM_053184
RefSeq (protein)	NP_001239203	NP_444414
Location (UCSC)	Chr 4: 69.59 – 69.65 Mb	Chr 5: 87.46 – 87.49 Mb
PubMed search	[1]	[2]

UDP glucuronosyltransferase 2 family, polypeptide B1, also known as UGT2B1, is an enzyme that in humans is encoded by the UGT2B1 gene.

Function

The olfactory neuroepithelium, which lines the posterior nasal cavity, is exposed to a wide range of odorants and airborne toxic compounds. Odorants, which are mostly small lipophilic molecules, enter the mucus flow and reach the odorant receptors on sensory neurons. Odorant sensing is generally a transient process, requiring an effective signal termination, which could be provided by biotransformation of the odorant in the epithelial supporting cells. Xenobiotic-metabolizing enzymes in the olfactory epithelium have been suggested to catalyze inactivation and facilitate elimination of odorants.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.