DPM3
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). dolichyl-phosphate mannosyltransferase polypeptide 3, also known as DPM3, is a human gene.[1][2]
Function
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a subunit of dolichyl-phosphate mannosyltransferase and acts as a stabilizer subunit of the dolichyl-phosphate mannosyltransferase complex.[1]
Clinical significance
Mutations in this gene are associated with congenital disorder of glycosylation type 1O.[3]
References
Further reading
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External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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