RhoGEF domain

RhoGEF domain
Structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein.
Identifiers
Symbol	RhoGEF
Pfam	PF00621
InterPro	IPR000219
SMART	RhoGEF
SCOP	1dbh
SUPERFAMILY	1dbh
OPM protein	1xd4
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

RhoGEF domain is a structural domain of guanine nucleotide exchange factors for Rho/Rac/Cdc42-like GTPases. It is also called "Dbl-homologous" (DH) domain.

Subfamilies

• Guanine-nucleotide dissociation stimulator, CDC24 IPR001331

Human proteins containing this domain

ABR; AKAP13; ARHGEF1; ARHGEF10; ARHGEF10L; ARHGEF11; ARHGEF12; ARHGEF15; ARHGEF16; ARHGEF17; ARHGEF18; ARHGEF19; ARHGEF2; ARHGEF3; ARHGEF4; ARHGEF5; ARHGEF6; ARHGEF7; ARHGEF9; ASEF2; BCR; C9orf100; DEPDC2; DNMBP; ECT2; FARP1; FARP2; FGD1; FGD2; FGD3; FGD4; FGD5; FGD6; GEFT; ITSN1; ITSN2; KALRN; LFDH; MCF2; MCF2L; MCF2L2; NET1; NGEF; OBSCN; PLEKHG1; PLEKHG2; PLEKHG3; PLEKHG4; PLEKHG5; PLEKHG6; PREX1; RASGRF1; SGEF; SOS1; SOS2; SPATA13; TIAM1; TIAM2; TRIO; VAV1; VAV2; VAV3;