CD59
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). CD59 glycoprotein also known as MAC-inhibitory protein (MAC-IP), membrane inhibitor of reactive lysis (MIRL), or protectin, is a protein that in humans is encoded by the CD59 gene.[1] It belongs to the LY6/uPAR/alpha-neurotoxin protein family.[2]
CD59 attaches to host cells via a glycophosphatidylinositol (GPI) anchor. When complement activation leads to deposition of C5b678 on host cells, CD59 can prevent C9 from polymerizing and forming the complement membrane attack complex.[3] It may also signal the cell to perform active measures such as endocytosis of the CD59-CD9 complex.[2]
Mutations affecting GPI that reduce expression of CD59 and decay-accelerating factor on red blood cells result in paroxysmal nocturnal hemoglobinuria.[4]
Viruses such as HIV, human cytomegalovirus and vaccinia incorporate host cell CD59 into their own viral envelope to prevent lysis by complement.[5]
References
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Further reading
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External links
- CD59 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
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