CD2

CD2 molecule
The protein structure of CD2. From PDB: 1hnf​
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1CDB, 1GYA, 1HNF, 1L2Z, 1QA9, 2J6O, 2J7I
Identifiers
Symbols	CD2 ; LFA-2; SRBC; T11
External IDs	OMIM: 186990 MGI: 88320 HomoloGene: 1338 ChEMBL: 2040 GeneCards: CD2 Gene
Gene ontology Molecular function • receptor activity • receptor binding • protein binding • protein homodimerization activity Cellular component • extracellular region • plasma membrane • integral component of plasma membrane • cell-cell junction • external side of plasma membrane • cytoplasmic side of plasma membrane • cell surface • anchored component of plasma membrane Biological process • membrane raft polarization • apoptotic process • cell surface receptor signaling pathway • blood coagulation • single organismal cell-cell adhesion • natural killer cell activation • positive regulation of myeloid dendritic cell activation • positive regulation of tumor necrosis factor production • heterotypic cell-cell adhesion • T cell activation • regulation of T cell differentiation • leukocyte migration • positive regulation of interferon-gamma secretion • positive regulation of interleukin-8 secretion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	914	12481
Ensembl	ENSG00000116824	ENSMUSG00000027863
UniProt	P06729	P08920
RefSeq (mRNA)	NM_001767	NM_013486
RefSeq (protein)	NP_001758	NP_038514
Location (UCSC)	Chr 1: 116.75 – 116.77 Mb	Chr 3: 101.28 – 101.29 Mb
PubMed search	[1]	[2]

CD2 (cluster of differentiation 2) is a cell adhesion molecule found on the surface of T cells and natural killer (NK) cells. It has also been called T-cell surface antigen T11/Leu-5, LFA-2, LFA-3 receptor, erythrocyte receptor and rosette receptor.

Function

It interacts with other adhesion molecules, such as lymphocyte function-associated antigen-3 (LFA-3/CD58) in humans, or CD48 in rodents, which are expressed on the surfaces of other cells.

In addition to its adhesive properties, CD2 also acts as a co-stimulatory molecule on T and NK cells.

Diagnostic relevance

CD2 is a specific marker for T cells and NK cells, and can therefore be used in immunohistochemistry to identify the presence of such cells in tissue sections. The great majority of T cell lymphomas and leukaemias also express CD2, making it possible to use the presence of the antigen to distinguish these conditions from B cell neoplasms.

Classification

Due to its structural characteristics, CD2 is a member of the immunoglobulin superfamily; it possesses two immunoglobulin-like domains in its extracellular portion.

Interactions

CD2 has been shown to interact with CD2BP2, Lck and PSTPIP1.

External links

• CD2 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
• Mouse CD Antigen Chart
• Human CD Antigen Chart