CD1A

CD1a molecule
PDB rendering based on 1onq.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1ONQ, 1XZ0, 4X6C, 4X6D, 4X6E, 4X6F
Identifiers
Symbols	CD1A ; CD1; FCB6; HTA1; R4; T6
External IDs	OMIM: 188370 HomoloGene: 113556 GeneCards: CD1A Gene
Gene ontology Molecular function • protein binding • beta-2-microglobulin binding • endogenous lipid antigen binding • exogenous lipid antigen binding • lipopeptide binding Cellular component • plasma membrane • integral component of plasma membrane • endosome membrane Biological process • adaptive immune response • immune response • antigen processing and presentation, exogenous lipid antigen via MHC class Ib Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	909	n/a
Ensembl	ENSG00000158477	n/a
UniProt	P06126	n/a
RefSeq (mRNA)	NM_001763	n/a
RefSeq (protein)	NP_001754	n/a
Location (UCSC)	Chr 1: 158.25 – 158.26 Mb	n/a
PubMed search	[1]	n/a

CD1a (Cluster of Differentiation 1a) is a human protein encoded by the CD1A gene.

This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined.

See also

• CD1

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.