Keratin 17

Keratin 17, type I
Keratin 17, type I
Identifiers
Symbols	KRT17 ; 39.1; CK-17; K17; PC; PC2; PCHC1
External IDs	OMIM: 148069 MGI: 96691 HomoloGene: 363 GeneCards: KRT17 Gene
Gene ontology
Molecular function	• structural constituent of cytoskeleton; • protein binding; • MHC class II receptor activity; • MHC class II protein binding;
Cellular component	• cytoplasm; • intermediate filament; • extracellular exosome; • cell periphery;
Biological process	• signal transduction; • epidermis development; • positive regulation of cell growth; • hair follicle morphogenesis; • keratinization; • intermediate filament organization; • positive regulation of translation; • positive regulation of hair follicle development;
	Sources: Amigo / QuickGO
RNA expression pattern
	File:PBB GE KRT17 205157 s at tn.png
	File:PBB GE KRT17 212236 x at tn.png
	More reference expression data
Orthologs
Species	Human
Entrez	3872
Ensembl	ENSG00000128422
UniProt	Q04695
RefSeq (mRNA)	NM_000422
RefSeq (protein)	NP_000413
Location (UCSC)	Chr 17:; 41.62 – 41.62 Mb
PubMed search	[1]
	v; t; e;

Keratin, type I cytoskeletal 17 is a protein that in humans is encoded by the KRT17 gene.^[1]^[2]^[3]^[4]

Keratin 17 is a type I cytokeratin. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in the gene encoding this protein lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex.^[4]

Interactions

Keratin 17 has been shown to interact with CCDC85B.^[5]

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.