Alpha catenin
catenin (cadherin-associated protein), alpha 1, 102kDa | |
---|---|
Identifiers | |
Symbol | CTNNA1 |
Entrez | 1495 |
HUGO | 2509 |
OMIM | 116805 |
RefSeq | NM_001903 |
UniProt | P35221 |
Other data | |
Locus | Chr. 5 q31.2 |
catenin (cadherin-associated protein), alpha 2 | |
---|---|
Identifiers | |
Symbol | CTNNA2 |
Entrez | 1496 |
HUGO | 2510 |
OMIM | 114025 |
RefSeq | NM_004389 |
UniProt | P26232 |
Other data | |
Locus | Chr. 2 p12-p11.1 |
catenin (cadherin-associated protein), alpha 3 | |
---|---|
Identifiers | |
Symbol | CTNNA3 |
Entrez | 29119 |
HUGO | 2511 |
OMIM | 607667 |
RefSeq | NM_013266 |
UniProt | Q9UI47 |
Other data | |
Locus | Chr. 10 q21 |
Alpha-catenin was suggested to function as a linking protein between cadherins and actin-containing filaments of the cytoskeleton.[1] It has been reported that the actin binding proteins vinculin[2] and alpha-actinin[3] can bind to alpha-catenin. However, a protein complex including a cadherin, actin, beta-catenin and alpha-catenin has not been isolated. It has been suggested that alpha-catenin does not bind with high affinity to both actin filaments and the E-cadherin-beta-catenin complex at the same time.[4] It has been observed that when alpha-catenin is not in a molecular complex with beta-catenin, it dimerizes and functions to regulate actin filament assembly, possibly by competing with Arp2/3 protein.[5]
The amino acid sequence of alpha-catenin has sequence similarity to that of vinculin.[6]
Contents
Types
There are three human alpha-catenin genes:
- alpha-1-catenin (also called alpha-E-catenin)
- alpha-2-catenin (also called alpha-N-catenin)
- alpha-3-catenin (also called alpha-T-catenin)
See also
External links
- alpha Catenin at the US National Library of Medicine Medical Subject Headings (MeSH)
References
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