Interleukin-1 receptor-associated kinase

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Interleukin-1 receptor-associated kinase is a family of kinases.^[1]

Types include:

See also

Interleukin-1 receptor

References

↑ Interleukin-1 Receptor-Associated Kinases at the US National Library of Medicine Medical Subject Headings (MeSH)

Kinases: Serine/threonine-specific protein kinases (EC 2.7.11-12)

Serine/threonine-specific protein kinases (EC 2.7.11.1-EC 2.7.11.20)

Non-specific serine/threonine protein kinases (EC 2.7.11.1)	LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated Mammalian target of rapamycin EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1
Pyruvate dehydrogenase kinase (EC 2.7.11.2)	PDK1 PDK2 PDK3
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)	AMP-activated protein kinase α PRKAA1 PRKAA2 β PRKAB1 PRKAB2 γ PRKAG1 PRKAG2 PRKAG3
(3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)) (EC 2.7.11.4)	BCKDK BCKDHA BCKDHB
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)	IDH2 IDH3A IDH3B IDH3G
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)	STK4
Myosin-heavy-chain kinase (EC 2.7.11.7)	Aurora kinase Aurora A kinase Aurora B kinase
Fas-activated serine/threonine kinase (EC 2.7.11.8)	FASTK STK10
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)	-
IκB kinase (EC 2.7.11.10)	CHUK IKK2 TBK1 IKBKE IKBKG IKBKAP
cAMP-dependent protein kinase (EC 2.7.11.11)	Protein kinase A PRKACG PRKACB PRKACA PRKY
cGMP-dependent protein kinase (EC 2.7.11.12)	Protein kinase G PRKG1
Protein kinase C (EC 2.7.11.13)	Protein kinase C Protein kinase Cζ PKC alpha PRKCB1 PRKCD PRKCE PRKCH PRKCG PRKCI PRKCQ Protein kinase N1 PKN2 PKN3
Rhodopsin kinase (EC 2.7.11.14)	Rhodopsin kinase
Beta adrenergic receptor kinase (EC 2.7.11.15)	Beta adrenergic receptor kinase Beta adrenergic receptor kinase-2
G-protein coupled receptor kinases (EC 2.7.11.16)	GRK4 GRK5 GRK6
Ca2+/calmodulin-dependent (EC 2.7.11.17)	BRSK2 CAMK1 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 MLCK CASK CHEK1 CHEK2 DAPK1 DAPK2 DAPK3 STK11 MAPKAPK2 MAPKAPK3 MAPKAPK5 MARK1 MARK2 MARK3 MARK4 MELK MKNK1 MKNK2 NUAK1 NUAK2 OBSCN PASK PHKG1 PHKG2 PIM1 PIM2 PKD1 PRKD2 PRKD3 PSKH1 SNF1LK2 KIAA0999 STK40 SNF1LK SNRK SPEG TSSK2 Kalirin TRIB1 TRIB2 TRIB3 TRIO Titin DCLK1
Myosin light-chain kinase (EC 2.7.11.18)	MYLK MYLK2 MYLK3 MYLK4
Phosphorylase kinase (EC 2.7.11.19)	PHKA1 PHKA2 PHKB PHKG1 PHKG2
Elongation factor 2 kinase (EC 2.7.11.20)	EEF2K STK19
Polo kinase (EC 2.7.11.21)	PLK1 PLK2 PLK3 PLK4

Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)

Polo kinase (EC 2.7.11.21)	PLK1 PLK2 PLK3 PLK4
Cyclin-dependent kinase (EC 2.7.11.22)	CDK1 CDK2 CDKL2 CDK3 CDK4 CDK5 CDKL5 CDK6 CDK7 CDK8 CDK9 CDK10 CDK12 CDC2L5 PCTK1 PCTK2 PCTK3 PFTK1 CDC2L1
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)	RPS6KA5 RPS6KA4 P70S6 kinase P70-S6 Kinase 1 RPS6KB2 RPS6KA2 RPS6KA3 RPS6KA1 RPS6KC1
Mitogen-activated protein kinase (EC 2.7.11.24)	Extracellular signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14
MAP3K (EC 2.7.11.25)	MAP kinase kinase kinases MAP3K1 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K6 MAP3K7 MAP3K8 RAFs ARAF BRAF KSR1 KSR2 MLKs MAP3K12 MAP3K13 MAP3K9 MAP3K10 MAP3K11 MAP3K7 ZAK CDC7 MAP3K14
Tau-protein kinase (EC 2.7.11.26)	TPK1 TTK GSK-3
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)	-
Tropomyosin kinase (EC 2.7.11.28)	-
Low-density-lipoprotein receptor kinase (EC 2.7.11.29)	-
Receptor protein serine/threonine kinase (EC 2.7.11.30)	Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

Dual-specificity kinases (EC 2.7.12)

MAP2K	MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

Proteins: enzymes

Activity

Regulation

Classification

Types

EC1 Oxidoreductases(list)
EC2 Transferases(list)
EC3 Hydrolases(list)
EC4 Lyases(list)
EC5 Isomerases(list)
EC6 Ligases(list)

Cytokine receptor modulators

See here instead.

Erythropoietin	Agonists: ARA-290 Asialo erythropoietin Carbamylated erythropoietin CNTO-530 Darbepoetin alfa Epoetin alfa Epoetin beta Epoetin kappa Epoetin zeta Erythropoietin (EPO) Erythropoietin-Fc Methoxy polyethylene glycol-epoetin beta (CERA/Mircera) Peginesatide Pegol sihematide (EPO-018B)
G-CSF (CSF3)	Agonists: Filgrastim Granulocyte colony-stimulating factor Lenograstim Pegfilgrastim
GM-CSF (CSF2)	Agonists: Granulocyte macrophage colony-stimulating factor Molgramostim Sargramostim Antibodies: Mavrilimumab MOR103 Namilumab
M-CSF (CSF1)	Agonists: Interleukin-34 Macrophage colony-stimulating factor
SCF (c-Kit)	See here instead.
Thrombopoietin	Agonists: Eltrombopag Promegapoietin Romiplostim Thrombopoietin (THPO, MGDF)

IFNAR (α/β, I)

Decoy receptors: Bifarcept

Agonists: Interferon gamma (IFN-γ)
Interferon gamma 1b

Antibodies: Fontolizumab

See here instead.

See here instead.

Agonists: Lymphotoxin (α (TNFβ), β (TNFC))

TNFR1	Agonists: TNF (TNFα; tasonermin)
TNFR2	Agonists: TNF (TNFα; tasonermin)
Ungrouped	Antibodies: Adalimumab Afelimomab Certolizumab pegol Golimumab Infliximab Nerelimomab Ozoralizumab Placulumab Decoy receptors: Etanercept Pegsunercept Other inhibitors: Apremilast Bupropion Catechins (green tea) Cannabinoids (cannabis, Echinacea purpurea) Curcumin (turmeric) LA-SS-Az Lenalidomide LSD Pentoxifylline Pomalidomide R-DOI TCB-2 Thalidomide

Others

TNF superfamily protein ligands: 4-1BBL (CD137L, TNFSF9)
APRIL (CD256, TNFSF13)
BAFF (CD257, TNFSF13B)
CAML
CD70 (CD27L, TNFSF7)
CD153 (CD30L, TNFSF8)
CD154 (CD40L, TNFSF5)
Ectodysplasin (A, A2)
FasL (CD95L, TNFSF6)
GITRL (TNFSF18)
LIGHT (HEVML, CD258, TNFSF14)
OX40L (CD252, TNFSF4)
RANKL (TRANCE, OPGL, ODF, CD254, TNFSF11)
Siva (CD27BP)
TRAIL (CD253, TNFSF10)
TWEAK (TNFSF12)
VEGI (TL1A, TNFSF15)

Other inhibitors: Blisibimod

Others

JAK
(inhibitors)

JAK1	Baricitinib CYT387 Filgotinib Ruxolitinib Tofacitinib (tasocitinib, CP-690550) Upadacitinib
JAK2	AG-490 Atiprimod AZD-1480 Baricitinib CHZ868 Cucurbitacin I (elatericin B, JSI-124) CYT387 Lestaurtinib NSC-7908 NSC-33994 Pacritinib Ruxolitinib SD-1008 Tofacitinib (tasocitinib, CP-690550)
JAK3	AG-490 Cercosporamide TCS-21311 Tofacitinib (tasocitinib, CP-690550) WHI-P 154 ZM-39923 ZM-449829

See also: Peptide receptor modulators
Growth factor receptor modulators

Molecular and Cellular Biology portal

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