CDKL2

Cyclin-dependent kinase-like 2 (CDC2-related kinase)
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4AAA, 4BBM
Identifiers
Symbols	CDKL2 ; KKIAMRE; P56
External IDs	OMIM: 603442 MGI: 1858227 HomoloGene: 55793 ChEMBL: 5728 GeneCards: CDKL2 Gene
EC number	2.7.11.22
Gene ontology Molecular function • protein kinase activity • cyclin-dependent protein serine/threonine kinase activity • ATP binding Cellular component • nucleus • nucleoplasm • cytoplasm • centrosome Biological process • protein phosphorylation • signal transduction • sex differentiation • regulation of cell cycle • positive regulation of protein targeting to mitochondrion Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE CDKL2 207073 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8999	53886
Ensembl	ENSG00000138769	ENSMUSG00000029403
UniProt	Q92772	Q9QUK0
RefSeq (mRNA)	NM_003948	NM_001276315
RefSeq (protein)	NP_003939	NP_001263244
Location (UCSC)	Chr 4: 75.58 – 75.63 Mb	Chr 5: 92.01 – 92.04 Mb
PubMed search	[1]	[2]

Cyclin-dependent kinase-like 2 is an enzyme that in humans is encoded by the CDKL2 gene.

This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the cytoplasm, with lower levels in the nucleus.