TGFBR3

Transforming growth factor, beta receptor III
Identifiers
Symbols	TGFBR3 ; BGCAN; betaglycan
External IDs	OMIM: 600742 MGI: 104637 HomoloGene: 2436 GeneCards: TGFBR3 Gene
Gene ontology Molecular function • transforming growth factor beta-activated receptor activity • type II transforming growth factor beta receptor binding • transforming growth factor beta receptor binding • protein binding • glycosaminoglycan binding • heparin binding • coreceptor activity • fibroblast growth factor binding • PDZ domain binding • SMAD binding • activin binding • transforming growth factor beta binding • transforming growth factor beta receptor activity, type III Cellular component • proteinaceous extracellular matrix • extracellular space • cytoplasm • integral component of plasma membrane • external side of plasma membrane • cell surface • inhibin-betaglycan-ActRII complex • receptor complex • extracellular exosome Biological process • response to hypoxia • epithelial to mesenchymal transition • liver development • heart morphogenesis • immune response • transforming growth factor beta receptor signaling pathway • transforming growth factor beta receptor complex assembly • cell growth • cell migration • BMP signaling pathway • positive regulation of transforming growth factor beta receptor signaling pathway • negative regulation of transforming growth factor beta receptor signaling pathway • organ regeneration • response to follicle-stimulating hormone • response to prostaglandin E • response to luteinizing hormone • intracellular signal transduction • regulation of protein binding • negative regulation of epithelial cell proliferation • negative regulation of cellular component movement • ventricular cardiac muscle tissue morphogenesis • palate development • cardiac muscle cell proliferation • definitive hemopoiesis • cardiac epithelial to mesenchymal transition • definitive erythrocyte differentiation • heart trabecula formation • pathway-restricted SMAD protein phosphorylation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7049	21814
Ensembl	ENSG00000069702	ENSMUSG00000029287
UniProt	Q03167	O88393
RefSeq (mRNA)	NM_001195683	NM_011578
RefSeq (protein)	NP_001182612	NP_035708
Location (UCSC)	Chr 1: 91.68 – 91.91 Mb	Chr 5: 107.11 – 107.29 Mb
PubMed search	[1]	[2]

Betaglycan also known as Transforming growth factor beta receptor III (TGFBR3), is a cell-surface chondroitin sulfate / heparan sulfate proteoglycan >300 kDa in molecular weight. Betaglycan binds to various members of the TGF-beta superfamily of ligands via its core protein, and bFGF via its heparan sulfate chains. It is not involved directly in TGF-beta signal transduction but by binding to various member of the TGF-beta superfamily at the cell surface it acts as a reservoir of ligand for TGF-beta receptors.

See also

• TGF beta receptors

External links

• betaglycan at the US National Library of Medicine Medical Subject Headings (MeSH)