ADBICA

ADBICA

Systematic (IUPAC) name
N-(1-Amino-3,3-dimethyl-1-oxobutan-2-yl)-1-pentyl-1H-indole-3-carboxamide
Clinical data
Legal status	CA: Schedule II
Identifiers
CAS Number	1445583-48-1 Y
ATC code	none
ChemSpider	29342130
Chemical data
Formula	C20H29N3O2
Molecular mass	343.46 g/mol
SMILES CCCCCN1C=C(C2=CC=CC=C21)C(=O)NC(C(=O)N)C(C)(C)C
InChI InChI=1S/C20H29N3O2/c1-5-6-9-12-23-13-15(14-10-7-8-11-16(14)23)19(25)22-17(18(21)24)20(2,3)4/h7-8,10-11,13,17H,5-6,9,12H2,1-4H3,(H2,21,24)(H,22,25) Key:IXUYMXAKKYWKRG-UHFFFAOYSA-N

ADBICA (also known as ADB-PICA) is a designer drug identified in synthetic cannabis blends in Japan in 2013. ADBICA had not previously been reported in the scientific literature prior to its sale as a component of synthetic cannabis blends. ADBICA features a carboxamide group at the 3-indole position, like SDB-001 and STS-135. The stereochemistry of the tert-butyl side-chain in the illicitly sold product is unresolved, though in a large series of indazole derivatives structurally similar to ADBICA that are disclosed in Pfizer patent WO 2009/106980, activity resides exclusively in the (S) enantiomers. ADBICA is a potent agonist of the CB₁ receptor and CB₂ receptor with a EC₅₀ value of 0.69 nM and 1.8 nM respectively.

Legal Status

As of October 2015 ADBICA is a controlled substance in China.

See also

• 5F-AB-PICA
• 5F-AB-PINACA
• 5F-ADB
• 5F-ADBICA
• 5F-AMB
• 5F-APINACA
• AB-FUBINACA
• AB-CHFUPYCA
• AB-CHMINACA
• AB-PINACA
• ADB-CHMINACA
• ADB-FUBINACA
• ADB-PINACA
• APICA
• APINACA
• MDMB-CHMICA
• PF-03550096
• SDB-001
• STS-135
• PX-3