Tuberous sclerosis complex tumor suppressors

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For the genetic disease, see Tuberous sclerosis.

Tuberous sclerosis complex (TSC) tumor suppressors form the TSC1-TSC2 molecular complex. Under poor growth conditions the TSC1-TSC2 complex limits cell growth.[1] A key promoter of cell growth, mTORC1, is inhibited by the tuberous sclerosis complex.[1] Insulin activates mTORC1 and causes dissociation of TSC from the surface of lysosomes.[2]

Resistance to ischemia-reperfusion injury by protein restriction is mediated by activation of the tuberous sclerosis complex.[3]

References

  1. ↑ 1.0 1.1 Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.


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