Template:PBB/27185

Disrupted in schizophrenia 1
Identifiers
Symbols	DISC1 ; C1orf136; SCZD9
External IDs	OMIM: 605210 MGI: 2447658 HomoloGene: 10257 GeneCards: DISC1 Gene
Gene ontology Molecular function • protein binding • kinesin binding • protein complex binding Cellular component • nucleus • mitochondrion • endoplasmic reticulum • centrosome • kinesin complex • microtubule • postsynaptic density • cell junction • dynein complex • axon • ciliary basal body • cell body • postsynaptic membrane • perinuclear region of cytoplasm • ciliary base Biological process • microtubule cytoskeleton organization • neuron migration • positive regulation of cell-matrix adhesion • positive regulation of neuroblast proliferation • cell proliferation in forebrain • pyramidal neuron migration • positive regulation of Wnt signaling pathway • TOR signaling • cellular protein localization • nonmotile primary cilium assembly • positive regulation of axon extension • mitochondrial calcium ion homeostasis • response to electrical stimulus • canonical Wnt signaling pathway • regulation of dendritic spine development • regulation of synapse maturation • positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE DISC1 206090 s at tn.png
File:PBB GE DISC1 207759 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	27185	244667
Ensembl	ENSG00000162946	ENSMUSG00000043051
UniProt	Q9NRI5	Q811T9
RefSeq (mRNA)	NM_001012957	NM_170596
RefSeq (protein)	NP_001012975	NP_777278
Location (UCSC)	Chr 1: 231.63 – 232.04 Mb	Chr 8: 125.05 – 125.26 Mb
PubMed search	[1]	[2]