TRAF1

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Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). TNF receptor-associated factor 1 is a protein that in humans is encoded by the TRAF1 gene.[1]

Function

The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors.[2]

Interactions

TRAF1 has been shown to interact with:

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References

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Further reading

  • Lua error in package.lua at line 80: module 'strict' not found.
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