Spectrin repeat

Spectrin repeat
Structure of the spectrin repeat: a left-handed antiparallel triple-helical coiled-coil.
Identifiers
Symbol	Spectrin
Pfam	PF00435
InterPro	IPR002017
PROSITE	PDOC50083
SCOP	1aj3
SUPERFAMILY	1aj3
OPM superfamily	79
OPM protein	2spc
CDD	cd00176
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Spectrin repeats are found in several proteins involved in cytoskeletal structure. These include spectrin, alpha-actinin, dystrophin and more recently the plakin family. The spectrin repeat forms a three-helix bundle. These conform to the rules of the heptad repeat. Spectrin repeats give rise to linear proteins. This however may be due to sample bias in which linear and rigid structures are more amenable to crystallization. There are hints however, that some proteins harbouring spectrin repeats may also be flexible. This is most likely due to specifically evolved functional purposes.

Human proteins containing this domain

ACTN1; ACTN2; ACTN3; ACTN4; AKAP6; SYNE3; CATX-15; DMD; DRP2; DST; KALRN; MACF1; MCF2L; SPTA1; SPTAN1; SPTB; SPTBN1; SPTBN2; SPTBN4; SPTBN5; SYNE1; SYNE2; TRIO; UTRN;