Sitafloxacin

Sitafloxacin

Systematic (IUPAC) name
7-[(4S)-4-Amino-6-azaspiro[2.4]heptan-6-yl]-8-chloro-6-fluoro-1-[(2S)-2-fluorocyclopropyl]-4-oxoquinoline-3-carboxylic acid
Clinical data
Legal status	℞ (Prescription only)
Routes of administration	Oral
Identifiers
CAS Number	127254-12-0 N
ATC code	J01MA21 (WHO)
PubChem	CID: 461399
ChemSpider	405945 Y
UNII	3GJC60U4Q8 N
ChEMBL	CHEMBL108821 Y
Chemical data
Formula	C19H18ClF2N3O3
Molecular mass	409.81
SMILES F[C@H]5C[C@H]5N2/C=C(/C(=O)O)C(=O)c1cc(F)c(c(Cl)c12)N4C[C@@H](N)C3(CC3)C4
InChI InChI=1S/C19H18ClF2N3O3/c20-14-15-8(17(26)9(18(27)28)5-25(15)12-4-10(12)21)3-11(22)16(14)24-6-13(23)19(7-24)1-2-19/h3,5,10,12-13H,1-2,4,6-7,23H2,(H,27,28)/t10-,12+,13+/m0/s1 Y Key:PNUZDKCDAWUEGK-CYZMBNFOSA-N Y
NY (what is this?)  (verify)

Sitafloxacin (INN; also called DU-6859a) is a fluoroquinolone antibiotic that shows promise in the treatment of Buruli ulcer. The molecule was identified by Daiichi Sankyo Co., which brought ofloxacin and levofloxacin to the market. Sitafloxacin is currently marketed in Japan by Daiichi Sankyo under the tradename Gracevit.

See also

• Quinolone

External links

• (Japanese) Gracevit グレースビット (PDF) Daiichi Sankyo Co. January 2008.