Serine racemase
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Serine racemase is an enzyme which generates D-serine from L-serine. D-serine acts as a neuronal signaling molecule by activating NMDA receptors in the brain. In humans, the serine racemase protein is encoded by the SRR gene.[1]
Mammalian serine racemase is a pyridoxal 5'-phosphate dependent enzyme that catalyzes both the racemization of L-serine to D-serine and also the elimination of water from L-serine, generating pyruvate and ammonia.[2] The enzyme is physiologically stimulated by divalent cations (e.g., magnesium) and is allosterically activated by the magnesium/ATP complex.
References
Further reading
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External links
- Serine racemase at the US National Library of Medicine Medical Subject Headings (MeSH)
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