Secretin family

File:1gcn opm.png Glucagon (1gcn)
Identifiers
Symbol	Hormone_2
Pfam	PF00123
InterPro	IPR000532
PROSITE	PDOC00233
SCOP	1gcn
SUPERFAMILY	1gcn
OPM protein	1gcn
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Glucagon/GIP/secretin/VIP hormones are a family of evolutionarily related peptide hormones that regulate activity of G-protein coupled receptors from secretin receptor family.

A number of polypeptidic hormones, mainly expressed in the intestine or the pancreas, belong to a group of these structurally related peptides. One such hormone, glucagon, is widely distributed and produced in the alpha-cells of pancreatic islets. It affects glucose metabolism in the liver by inhibiting glycogen synthesis, stimulating glycogenolysis and enchancing gluconeogenesis. It also increases mobilisation of glucose, free fatty acids and ketone bodies, which are metabolites produced in excess in diabetes mellitus. Glucagon is produced, like other peptide hormones, as part of a larger precursor (preproglucagon), which is cleaved to produce glucagon, glucagon-like protein I, glucagon-like protein II, and glicentin. The structure of glucagon itself is fully conserved in all mammalian species in which it has been studied. Other members of the structurally similar group include secretin, gastric inhibitory peptide, vasoactive intestinal peptide (VIP), prealbumin, peptide HI-27 and growth hormone releasing factor.

Human hormones from this family

ADCYAP1; GCG; GHRH; GIP; SCT; VIP;

References

This article incorporates text from the public domain Pfam and InterPro IPR000532