RUVBL2

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Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). RuvB-like 2 (E. coli), also known as RUVBL2, is a human gene coding for a protein belonging to the AAA+ family of proteins.

Function

This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. However, the evidence for whether RUVBL2 has DNA helicase activity is contradictory.[1] This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation.[2]

Interactions

RUVBL2 has been shown to interact with RuvB-like 1[3] and Activating transcription factor 2.[4]

References

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Further reading

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