Pilomatricoma
| Pilomatricoma | |
|---|---|
| File:Pilomatrixoma - high mag.jpg
Micrograph of a pilomatricoma showing the characteristic "ghost" cells (anucleate squamous cells), benign viable squamous cells and multi-nucleated giant cells. H&E stain.
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| Classification and external resources | |
| Specialty | Lua error in Module:Wikidata at line 446: attempt to index field 'wikibase' (a nil value). |
| ICD-10 | D23 |
| DiseasesDB | 32128 |
| eMedicine | article/1058965 |
| Patient UK | Pilomatricoma |
Pilomatricoma, also known as a calcifying epithelioma of Malherbe,[1] Malherbe calcifying epithelioma, and Pilomatrixoma, is a benign skin tumor derived from the hair matrix.[2]:670[3]
Histologic features
Pilomatricomas consist of anucleate squamous cells (called "ghost cells"), benign viable squamous cells and multi-nucleated giant cells. The presence of calcifications is common.
Pathogenesis
Pilomatricoma is associated with high levels of beta-catenin caused by either a mutation in the APC gene or beta-catenin gene. These high levels of beta-catenin can aid cell proliferation, inhibit cell death, and ultimately lead to cancer.[4]
Associations
Pilomatricomas are associated with Turner syndrome, with a prevalence of 2.6%.[5] In addition to Turner syndrome, multiple pilomatricomas are associated with myotonic dystrophy, Rubinstein-Taybi syndrome, and trisomy 9.[6]
See also
- Malignant pilomatricoma
- List of cutaneous conditions
- List of cutaneous neoplasms associated with systemic syndromes
References
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Hassanein AM, Glanz SM, Kessler HP, Eskin TA, Liu C (2003). "beta-Catenin is expressed aberrantly in tumors expressing shadow cells. Pilomatricoma, craniopharyngioma, and calcifying odontogenic cyst". Am J Clin Pathol (5):732-6. PMID 14608900.
- ↑ Handler MZ, Derrick KM, Lutz RE, Morrell DS, Davenport ML, Armstrong AW (2013). "Prevalence of pilomatricoma in Turner syndrome: findings from a multicenter study". JAMA Dermatol 149(5):559-64. PMID 23426075.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
