NEDD1

Neural precursor cell expressed, developmentally down-regulated 1
Identifiers
Symbols	NEDD1 ; GCP-WD; TUBGCP7
External IDs	OMIM: 600372 MGI: 97293 HomoloGene: 7439 GeneCards: NEDD1 Gene
Gene ontology Cellular component • pericentriolar material • spindle pole • nucleoplasm • nucleolus • centrosome • centriole • cytosol • plasma membrane • ciliary basal body • apical part of cell Biological process • G2/M transition of mitotic cell cycle • mitotic cell cycle • organelle organization • mitotic nuclear division • cell division Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE NEDD1 gnf1h02668 at tn.png
File:PBB GE NEDD1 gnf1h02669 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	121441	17997
Ensembl	ENSG00000139350	ENSMUSG00000019988
UniProt	Q8NHV4	P33215
RefSeq (mRNA)	NM_001135175	NM_008682
RefSeq (protein)	NP_001128647	NP_032708
Location (UCSC)	Chr 12: 96.91 – 96.95 Mb	Chr 10: 92.68 – 92.72 Mb
PubMed search	[1]	[2]

Neural precursor cell expressed, developmentally down-regulated 1, also known as Nedd1, is a human gene and encodes the protein NEDD1.

NEDD1 is localized in the centrosome and it plays a role in mitosis through its interaction with γ-tubulin. WD40 repeats are located in the amino-terminal of the protein and are responsible for NEDD1 localization in the centrosome, and the carboxy-terminal amino acids are needed for interactions with γ-tubulin. Depletion of NEDD1 causes impaired centrosome and chromatin microtubules assembly that results in the failure of microtubule nucleation and prevents proper spindle formation.