HMG-box
| HMG (high mobility group) box | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| 300px
NMR structure of the HMG-box domain of the LEF1 protein (rainbow colored, N-terminus = blue, C-terminus = red) complexed with DNA (brown) based on the PDB: 2LEF coordinates.
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| Identifiers | |||||||||
| Symbol | PF00505 | ||||||||
| Pfam | PF00505 | ||||||||
| InterPro | IPR009071 | ||||||||
| SCOP | 1hsm | ||||||||
| SUPERFAMILY | 1hsm | ||||||||
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The HMG-box (High Mobility Group box) is a protein domain which is involved in DNA binding.[1]
Structure
The structure of the HMG-box domain contains three alpha helices separated by loops (see figure to the right).[2]
Function
HMG-box containing proteins only bind non-B-type DNA conformations (kinked or unwound) with high affinity.[1] HMG-box domains are found in high mobility group proteins, which are involved in the regulation of DNA-dependent processes such as transcription, replication, and DNA repair, all of which require changing the conformation of chromatin.[2]
References
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<references />, or <references group="..." />External links
- HMG-Box Domains at the US National Library of Medicine Medical Subject Headings (MeSH)
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