HIST1H4E

Histone cluster 1, H4e
250px PDB rendering based on 1aoi.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1ZKK, 2BQZ, 2CV5, 2IG0, 2KWN, 2KWO, 2LVM, 2QQS, 2RJE, 2RNY, 2RS9, 3A6N, 3AFA, 3AN2, 3AV1, 3AV2, 3AYW, 3AZE, 3AZF, 3AZG, 3AZH, 3AZI, 3AZJ, 3AZK, 3AZL, 3AZM, 3AZN, 3CFS, 3CFV, 3F9W, 3F9X, 3F9Y, 3F9Z, 3IJ1, 3JPX, 3NQJ, 3NQU, 3O36, 3QBY, 3QZS, 3QZT, 3QZV, 3R45, 3UVW, 3UVX, 3UVY, 3UW9, 3W96, 3W97, 3W98, 3W99, 3WA9, 3WAA, 3WKJ, 3WTP, 4GQB, 4H9N, 4H9O, 4H9P, 4H9Q, 4H9R, 4H9S, 4HGA, 4M38, 4N3W, 4N4F, 4QUT, 4QUU, 4QYD
Identifiers
Symbols	HIST1H4E ; H4/j; H4FJ
External IDs	OMIM: 602830 HomoloGene: 134463 GeneCards: HIST1H4E Gene
Gene ontology Molecular function • DNA binding • protein binding • histone demethylase activity (H4-K20 specific) • histone binding • poly(A) RNA binding • protein heterodimerization activity Cellular component • nuclear chromosome • nucleosome • extracellular region • nucleus • nucleoplasm • membrane • protein complex • extracellular exosome Biological process • chromatin silencing at rDNA • mitotic cell cycle • telomere maintenance • chromatin organization • nucleosome assembly • DNA replication-dependent nucleosome assembly • DNA replication-independent nucleosome assembly • small GTPase mediated signal transduction • gene expression • DNA methylation on cytosine • CENP-A containing nucleosome assembly • histone H4-K20 demethylation • regulation of gene expression, epigenetic • negative regulation of megakaryocyte differentiation • negative regulation of gene expression, epigenetic • protein heterotetramerization Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8367	n/a
Ensembl	ENSG00000276966	n/a
UniProt	P62805	n/a
RefSeq (mRNA)	NM_003545	n/a
RefSeq (protein)	NP_003536	n/a
Location (UCSC)	Chr 6: 26.2 – 26.2 Mb	n/a
PubMed search	[1]	n/a

Histone H4 is a protein that in humans is encoded by the HIST1H4E gene.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.