HDAC4

Histone deacetylase 4, also known as HDAC4, is a protein that in humans is encoded by the HDAC4 gene.

Function

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. Furthermore, HDAC4 is required for TGFbeta1-induced myofibroblastic differentiation.

Clinical significance

Studies have shown that HDAC4 regulates bone and muscle development. Harvard University researchers also concluded that it promotes healthy vision: Reduced levels of the protein led to the death of the rod photoreceptors and bipolar cells in the retinas of mice.

Interactions

HDAC4 has been shown to interact with:

• BCL6,
• BTG2,
• CBX5,
• GATA1,
• HDAC3,
• MAPK1,
• MAPK3,
• MEF2C,
• Myocyte-specific enhancer factor 2A,
• Nuclear receptor co-repressor 1,
• Nuclear receptor co-repressor 2,
• Testicular receptor 2,
• YWHAB,
• YWHAE, and
• Zinc finger and BTB domain-containing protein 16.

See also

• Histone deacetylase

External links

• HDAC4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.