HDAC1

Histone deacetylase 1 is an enzyme that in humans is encoded by the HDAC1 gene.

Function

Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2 MTA2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.

Model organisms

Hdac1 knockout mouse phenotype

Characteristic	Phenotype
Homozygote viability	Abnormal
Recessive lethal study	Abnormal
Fertility	Normal
Body weight	Normal
Anxiety	Normal
Neurological assessment	Normal
Grip strength	Normal
Hot plate	Normal
Dysmorphology	Normal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Normal
Radiography	Normal
Body temperature	Normal
Eye morphology	Normal
Clinical chemistry	Normal
Haematology	Normal
Peripheral blood lymphocytes	Normal
Micronucleus test	Normal
Heart weight	Normal
Brain histopathology	Normal
Eye Histopathology	Normal
Salmonella infection	Normal
Citrobacter infection	Normal
All tests and analysis from

Model organisms have been used in the study of HDAC1 function. A conditional knockout mouse line, called Hdac1^{tm1a(EUCOMM)Wtsi} was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty five tests were carried out and two phenotypes were reported. A reduced number of homozygous mutant embryos were identified during gestation, and none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice, and no significant abnormalities were observed in these animals.

Interactions

HDAC1 has been shown to interact with:

• Androgen receptor,
• BCL6,
• BTG2,
• BUB1B,
• BUB1,
• BUB3,
• CBFA2T3,
• CDC20,
• CDH1,
• CHD3,
• CHD4,
• COUP-TFII,
• CTBP1,
• DDX17,
• DDX5,
• DNMT3A,
• DNMT3L,
• Death-associated protein 6,
• EED,
• EVI1,
• EZH2,
• FKBP3,
• GATA1,
• HMG20B,
• HSPA4,
• HUS1,
• Histone deacetylase 2,
• Homeobox protein TGIF1,
• Host cell factor C1,
• IFRD1,
• IKZF1,
• ING1,
• MBD3,
• MIER1,
• MLL,
• MTA1,
• MTA2,
• Mad1,
• Mdm2,
• Methyl-CpG-binding domain protein 2,
• Mothers against decapentaplegic homolog 2,
• MyoD,
• NFKB1,
• Nuclear receptor co-repressor 2,
• PCNA,
• PHF21A,
• Prohibitin,
• Promyelocytic leukemia protein,
• RAD9A,
• RBBP4,
• RBBP7,
• RCOR1,
• RELA,
• RFC1,
• Retinoblastoma protein,
• Retinoblastoma-like protein 1,
• Retinoblastoma-like protein 2,
• SAP30,
• SATB1,
• SIN3A,
• SIN3B,
• SPEN,
• SUDS3,
• SUV39H1,
• Sp1 transcription factor,
• TOP2A,
• TOP2B, and
• Zinc finger and BTB domain-containing protein 16.

See also

• Histone deacetylase
• Histone deacetylase inhibitor

External links

• HDAC1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)