H2AFB2

H2A histone family, member B2
Identifiers
Symbols	H2AFB2 ;
External IDs	MGI: 3644980 GeneCards: H2AFB2 Gene
Gene ontology Molecular function • DNA binding Cellular component • nucleus • chromosome • nucleosome Biological process • nucleosome assembly Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	474381	624153
Ensembl	ENSG00000198307	ENSMUSG00000082482
UniProt	P0C5Z0	n/a
RefSeq (mRNA)	NM_001017991	XM_888672
RefSeq (protein)	NP_001017991	XP_893765
Location (UCSC)	Chr X: 154.61 – 154.61 Mb	Chr X: 113.79 – 113.8 Mb
PubMed search	[1]	[2]

Histone H2A-Bbd type 2/3 also known as H2A Barr body-deficient is a histone protein that in humans is encoded by the H2AFB2 gene (H2A histone family, member B1).

Function

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. This gene is part of a region that is repeated three times on chromosome X, once in intron 22 of the F8 gene and twice closer to the Xq telomere. This record represents the middle copy.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.