H1FOO

H1 histone family, member O, oocyte-specific
Identifiers
Symbols	H1FOO ; H1.8; osH1
External IDs	MGI: 2176207 HomoloGene: 51377 GeneCards: H1FOO Gene
Gene ontology Molecular function • nucleosomal DNA binding Cellular component • nucleosome • female germ cell nucleus • nucleus • nucleolus • cytoplasm • extracellular exosome Biological process • nucleosome assembly • nucleosome positioning • regulation of DNA methylation • meiotic cell cycle • negative regulation of stem cell differentiation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	132243	171506
Ensembl	ENSG00000178804	ENSMUSG00000042279
UniProt	Q8IZA3	Q8VIK3
RefSeq (mRNA)	NM_001308262	NM_138311
RefSeq (protein)	NP_001295191	NP_612184
Location (UCSC)	Chr 3: 129.54 – 129.55 Mb	Chr 6: 115.94 – 115.95 Mb
PubMed search	[1]	[2]

Histone H1oo is a protein that in humans is encoded by the H1FOO gene.

Function

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a member of the histone H1 family. This gene contains introns, unlike most histone genes. The protein encoded is a member of the histone H1 family. The related mouse gene is expressed only in oocytes.

It incorporates into sperm chromatin after fertilisation.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.