Cilastatin
From Infogalactic: the planetary knowledge core
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Systematic (IUPAC) name | |
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(Z)-7-[(2R)-2-Amino-3-hydroxy-3-oxopropyl]sulfanyl-2-{[(1S)-2,2-dimethylcyclopropanecarbonyl]amino}hept-2-enoic acid
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Clinical data | |
AHFS/Drugs.com | International Drug Names |
MedlinePlus | a686013 |
Routes of administration |
IV |
Identifiers | |
CAS Number | 82009-34-5 ![]() |
ATC code | J01DH51 (WHO) (combination with imipenem) |
PubChem | CID: 5280454 |
IUPHAR/BPS | 5166 |
DrugBank | DB01597 ![]() |
ChemSpider | 4940183 ![]() |
UNII | 141A6AMN38 ![]() |
KEGG | D07698 ![]() |
ChEBI | CHEBI:3697 ![]() |
ChEMBL | CHEMBL766 ![]() |
Chemical data | |
Formula | C16H26N2O5S |
Molecular mass | 358.454 g/mol |
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Cilastatin is a chemical compound which inhibits the human enzyme dehydropeptidase.[1]
Dehydropeptidase is an enzyme found in the kidney and is responsible for degrading the antibiotic imipenem. Cilastatin can therefore be combined intravenously with imipenem in order to protect it from dehydropeptidase and prolong its antibacterial effect. Imipenem alone is an effective antibiotic and can be given without the cilastatin. Cilastatin itself does not have antibiotic activity.
See also
References
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