CRTC1
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CREB-regulated transcription coactivator 1 (CRTC1), previously referred to as TORC1 (Transducer Of Regulated CREB activity 1), is a protein that in humans is encoded by the CRTC1 gene.[1][2][3][4] It is expressed in a limited number of tissues that include fetal brain and liver and adult heart, skeletal muscles, liver and salivary glands[5] and various regions of the adult central nervous system.[6]
Clinical significance
Production of CRTC1 is blocked in Alzheimer's disease.[7] TORC1 might be the target protein in ketamin induced anti-depressent effect via NMDA-antagonisation.
See also
References
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Further reading
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External links
- CRTC1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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