BD1008

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BD1008
BD1008.png
Systematic (IUPAC) name
N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-1-pyrrolidineethanamine
Identifiers
CAS Number 138356-08-8
PubChem CID: 126388
ChemSpider 112324
Chemical data
Formula C15H22Cl2N2
Molecular mass 301.25 g/mol
  • CN(CCc1ccc(c(c1)Cl)Cl)CCN2CCCC2
  • InChI=1S/C15H22Cl2N2/c1-18(10-11-19-7-2-3-8-19)9-6-13-4-5-14(16)15(17)12-13/h4-5,12H,2-3,6-11H2,1H3
  • Key:ASGIQUHBAVIOTI-UHFFFAOYSA-N

BD1008 or N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-1-pyrrolidineethanamine is a selective sigma receptor antagonist, with a reported binding affinity of Ki = 2 ± 1 nM for the sigma-1 receptor and 4 times selectivity over the sigma-2 receptor.[1]

Consistent with other reported sigma receptor antagonists, pretreating Swiss Webster mice with BD1008 significantly attenuates the behavioral toxicity of cocaine, and may be potentially useful in the development of antidotes for the treatment of cocaine overdose.[1][2][3][4]

See also

References

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