Antimony potassium tartrate

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Antimony potassium tartrate trihydrate
Potassium antimonyl tartrate.png
Names
Other names
potassium antimonyl tartrate
emetic tartar
tartar emetic
Identifiers
28300-74-5
ChEBI CHEBI:2761
ChemSpider 17214979
EC Number 234-293-3
Jmol 3D model Interactive image
KEGG C11340
PubChem 16682736
  • InChI=1S/2C4H4O6.2K.3H2O.2Sb/c2*5-1(3(7)8)2(6)4(9)10;;;;;;;/h2*1-2H,(H,7,8)(H,9,10);;;3*1H2;;/q2*-2;2*+1;;;;2*+3/p-4
    Key: WBTCZEPSIIFINA-UHFFFAOYSA-J
  • [K+].[K+].[H]O[H].[H]O[H].[H]O[H].O=C1O[Sb-]23OC1C1O[Sb-]4(OC(C(O2)C(=O)O3)C(=O)O4)OC1=O
Properties
K2Sb2(C4H2O6)2 · 3 H2O
Molar mass 667.87 g/mol
Appearance white crystalline powder
Density 2.6 g/cm3
8.3 g/100 mL (0 °C)
35.9 g/100 mL (100 °C)
Vapor pressure {{{value}}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Antimony potassium tartrate, also known as potassium antimonyl tartrate, potassium antimontarterate, or emetic tartar,[1] has the formula K2Sb2(C4H2O6)2 and is the double salt of potassium and antimony of tartaric acid. The compound has long been known as a powerful emetic, and was used in the treatment of schistosomiasis and leishmaniasis.

Emetic

500 mg tartar emetic

Antimony potassium tartrate's potential as an emetic was known since the Middle Ages. The compound itself was considered toxic and therefore a different way to administer it was found. Cups made from pure antimony were used to store wine for 24 hours and then the resulting solution of antimony potassium tartrate in wine was consumed in small portions until the wanted emetic effect was reached.[2][3][4]

Today, the compound is still used to induce vomiting in captured animals to study their diet.[5][6][7]

Medical

The first treatment application against trypanosomiasis was tested in 1906, and the compound's use to treat other tropical diseases was researched.[8] The treatment of leishmania with antimony potassium tartrate started in 1913. After the introduction of antimony (V) containing complexes like sodium stibogluconate and meglumine antimoniate, the use of antimony potassium tartrate was phased out.[8][9] After British physician John Brian Christopherson's discovery in 1918 that antimony potassium tartrate could cure schistosomiasis, the antimonial drugs became widely used.[10][11][12] However, the injection of antimony potassium tartrate had severe side effects such as Adams–Stokes syndrome[13] and therefore alternative substances were under investigation. With the introduction and subsequent larger use of praziquantel in the 1970s, the use of antimony based treatments fell out of use.[14][15]

Tartar emetic was used in the late 19th and early 20th century in patent medicine as remedy for alcohol intoxication, and was first ruled ineffective in the United States in 1941, in United States v. 11 1/4 Dozen Packages of Articles Labeled in Part Mrs. Moffat’s Shoo-Fly Powders for Drunkenness.[16][17]

The New England Journal of Medicine[18] reported a case study of a patient whose wife secretly gave him a dose of a product called "tartaro emetico" which contained trivalent antimony (antimony potassium tartrate) and is sold in Central America as an aversive treatment for alcohol abuse. The patient, who had been out drinking the night before, developed persistent vomiting shortly after being given orange juice with the drug. When admitted to the hospital, and later in the ICU, he experienced severe chest pains, cardiac abnormalities, renal and hepatic toxicity, and nearly died. The Journal reports that "Two years later, he [the patient] reports complete abstinence from alcohol."

Preparation

Antimony potassium tartrate can be prepared by refluxing a solution of potassium hydrogen tartrate and antimony trioxide for 15 minutes. The hot mixture is then filtered and crystals of Antimony potassium tartrate precipitates out as a colourless crystals.[19][20]

References

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Further reading

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