ATF3

Cyclic AMP-dependent transcription factor ATF-3 is a protein that, in humans, is encoded by the ATF3 gene.

Function

Activating transcription factor 3 is a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. Multiple transcript variants encoding two different isoforms have been found for this gene. The longer isoform represses rather than activates transcription from promoters with ATF binding elements. The shorter isoform (deltaZip2) lacks the leucine zipper protein-dimerization motif and does not bind to DNA, and it stimulates transcription, it is presumed, by sequestering inhibitory co-factors away from the promoter. It is possible that alternative splicing of the ATF3 gene may be physiologically important in the regulation of target genes.

Clinical significance

ATF-3 is induced upon physiological stress in various tissues. It is also a marker of regeneration following injury of dorsal root ganglion neurons in Pain Research.

See also

• Activating transcription factor

Interactions

ATF3 has been shown to interact with:

• C-jun,
• DDIT3
• JunD,
• P53, and
• SMAD3.

External links

• ATF3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• FactorBook ATF3

This article incorporates text from the United States National Library of Medicine, which is in the public domain.