Mincle receptor
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Mincle receptor, macrophage inducible Ca2+-dependent (C-type) lectin; CLEC4E is a calcium-dependent lectin that is a receptor for mycobacterial cord factor, trehalose-6,6'-dimycolate (TDM).[1][2] As a C-type lectin, the mincle receptor binds a range of carbohydrate structures, predominantly containing glucose or mannose, and play an important role in recognition of bacterial glycolipids by the immune system. Upon activation by cord factor, Mincle binds the Fc receptor FcγR and Syk. Cord factor also binds and activates the related C-type lectin MCL; CLEC4D.[3]
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